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Solid dispersions project thesis proposal

Solid dispersions project thesis proposal including paracetamol


Poor water solubility is characterised by low dissolution rate and therefore reduced bioavailability. Formulation of solid dispersion from the drug has attracted considerable interest as a way of improving dissolution procedure for a variety of poorly water soluble drugs. This current study investigates the formulation of solid dispersion for a variety of poorly water soluble drugs with different physicochemical qualities including paracetamol, sulphamethoxazole, phenacetin, indomethacin, chloramphenicol, phenylbutazone and succinylsulphathiazole. Solid dispersions were prepared using various drugs to polymer ratios. PEG 8000 was selected like a carrier within the solid dispersions. The research says inclusion of drug inside the polymeric matrix, ratio of drug to polymer and physicochemical qualities from the drug molecules boost the dissolution rate. Characterisations from the solid dispersions were performed using DSC, FTIR and SEM. These studies says all seven drugs were contained in the amorphous form inside the solid dispersions there was deficiencies in interaction between your PEG 8000 and drug. Stability studies for solid dispersions demonstrated that seven drugs studied were unstable at faster conditions (40°C±2°C/75%RH±5%RH) whereas, these were discovered to be stable for 12 several weeks at room conditions. Permeability of indomethacin, phenacetin, phenylbutazone and paracetamol were greater for solid dispersions when compared with drug alone across Caco-2 cell monolayers. In the cell uptake studies it had been proven that PEG 8000 enhanced rhodamine123 uptake which recommended that PEG 8000 could raise the permeability of those drugs in solid dispersions.

Solid dispersions project thesis proposal the solid

Gene expression profiles analyzing the expression alterations in the ABC and solute carrier transporter during permeability studies.ABCA10, ABCB4, ABCC12, SLC12A6, MCT13, SLC22A12 and SLC6A6 gene expression were elevated by indomethacin alone whereas solid dispersion of indomethacin led to a small rise in expression. ABCC12 and SAMC gene expression was elevated in situation of paracetamol alone but slightly elevated when uncovered to solid dispersion of paracetamol.

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Solid dispersions,formulation,characterisation,permeability,genomic evaluation,low dissolution

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