Abstract

Self-emulsifying drug delivery systems (SEDDS) are mixtures of oils and surfactants, ideally isotropic, sometimes including cosolvents, which emulsify under conditions of gentle agitation, much like individuals which may be experienced within the gastro-digestive tract. Hydrophobic drugs can frequently be dissolved in SEDDS letting them be encapsulated as unit dosage forms for peroral administration. When this type of formulation is released in to the lumen from the gut it disperses to create a fine emulsion, so the drug remains in solution within the gut, staying away from the dissolution step which regularly limits the speed of absorption of hydrophobic drugs in the crystalline condition. Generally this may lead to improved bioavailability, and/or perhaps a more consistent temporal profile of absorption in the gut. Ultra-low oil-water interfacial tension and/or substantial interfacial disruption are needed to attain self-emulsification. SEDDS are often formulated with triglyceride oils and ethoxylated nonionic surfactants, usually at surfactant concentrations more than 25%. Used, disruption from the oil-water interface is because transmission water in to the formulation or diffusion of cosolvents from the formulation. These two phenomena could be studied using equilibrium phase diagrams, which in conjunction with particle size measurements permit the optimisation of performance of SEDDS. The actual mechanisms of emulsification remain the topic of speculation but there’s an empirical outcomes of self-emulsification, live view screen formation, oil-water phase-inversion temperature that has been enhanced solubilization water by oily formulations, which phenomena are indicators from the efficiency of emulsification.

This short article describes strategies employed for formulation of SEDDS, methods employed for assessment of efficiency of emulsification and practical factors regarding using SEDDS for enhancement from the bioavailability of medication in the gastro-digestive tract.

Keywords

• Self-emulsifying drug delivery systems (SEDDS)
• Self-emulsification
• Spontaneous emulsification
• Nonionic surfactants
• Phase conduct
• Liquid crystals
• Triglycerides
• Bioavailability

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1997 Printed by Elsevier B.V.

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