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Ratnamala Dutta. Raj Biswas. Somenath Bhattacharya and Sonia Auddy

Gastroretentive drug delivery system is among the important methods to achieve gastric retention to acquire sufficient drug bioavailability. This delivery systems is desirable for drugs by having an absorption window within the stomach or perhaps in top of the small intestine. This possess a bulk density under gastric fluid the medication is released gradually like a preferred rate in the system. After discharge of drug, the rest of the product is emptied in the stomach. This lead to an elevated gastric retention time (GRT) a much better charge of the fluctuation in plasma drug concentration.
Here, we use glipizide because the candidate drug that your second generation sulfonyl urea utilized as an anti-diabetic drug. It undergoes enterohepatic circulation.

It functions on sulfonyl urea receptor. It creates action by blocking potassium funnel in -cell of islet of langerhans through which calcium funnel get activated increase more insulin release from individual -cell. Gellan gum, magnesium stearate can be used for the formulation of the glipizide microbeads. Here, we identify the sizes, densities, percentages of swelling of glipizide beads percentages of drug entrapment efficiency to exhibit that it could affect release duration of active component in tablet although not lessen the overall bioavailability of candidate drug.

4352.pdf