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Sustain release matrix tablets thesis proposal

Sustain release matrix tablets thesis proposal with the

[Show abstract] [Hide abstract] ABSTRACT: Sustained-release drug delivery system that contains Ranolazine (an anti-anginal drug) with various ratios of pH dependent polymer, Eudragit L100-55 was created by wet granulation method. The physicochemical compatibility from the drug and polymers were studied by FTIR spectrophotometer and discovered to be compatible. The in vitro discharge of Ranolazine SR tablets was studied in 900 ml of .1N HCl as dissolution medium utilizing a USP dissolution paddle set up at 50 revoltions per minute and 37±0.5°C. The promising formulation with power of Eudragit L100-55 polymer 12.5% demonstrated better discharge of 99.78±0.99% after 24 hrs. It demonstrated Zero-order release with linearity (r=.9447 to .9895). The similarity factor (f2 values) was utilized for that comparison of in vitro release study of the greatest formulation of SR tablets and marketed ER product of Ranolazine. The f2 values discovered to be 77.29. In line with the similarity factor (f2 values), the F4 formulation of SR tablets can be viewed as as enhanced formulation in comparison to marketed ER product&#x27s drug release profile. To review the mechanism of drug release in the dental SR tablets of Ranolazine, the discharge data were suited to the well-known exponential equation (Korsmeyer/Peppa&#x27s equation) and &#x27p&#x27 values discovered to be .73-.78. This signifies the discharge of drug follows non -fickian transport. Therefore, the present study signifies the formulation F4 from the dental sustained release tablets of Ranolazine provides a more sensible choice for growth and development of dental SR tablets of Ranolazine at least-daily administration.

Sustain release matrix tablets thesis proposal SUSTAIN RELEASE FORMULATION AND EVALUATION

Full-text · Article · · Der Pharmacia Lettre

M Ranga Priya R Natarajan N N Rajendran

[Show abstract] [Hide abstract] ABSTRACT: The goal of this research ended up being to design dental sustained release matrix tablets of Ranolazine using hydroxypropyl methylcellulose (HPMC) because the retardant polymer and also to read the aftereffect of formulation factors for example polymer proportion and polymer viscosity around the discharge of drug. In vitro release studies were performed using USP type II apparatus (paddle method) in 900 mL of .1N HCl at 100 revoltions per minute for 12 hrs. The discharge kinetics was examined while using zero-order, first order, Higuchi and Korsmeyer-Peppas equations to understand more about and explain the mechanism of drug release in the matrix tablets. In vitro release studies says the discharge rate decreased with rise in polymer proportion and viscosity grade. Mathematical research into the release kinetics established that the character of drug release in the matrix tablets was determined by drug diffusion and polymer relaxation and for that reason adopted non-Fickian or anomalous release. The developed controlled release matrix tablets of Ranolazine prepared rich in viscosity HPMC extended release as much as 12 hrs.

Full-text · Article · Jun 2010

[Show abstract] [Hide abstract] ABSTRACT: Ranolazine is definitely an anti-anginal drug with extensive and highly variable hepatic first pass metabolic process following dental administration, with systemic bio-accessibility to 76% and ranolazine also offers a comparatively short plasma half-existence of two.5±0.5 hrs.

Sustain release matrix tablets thesis proposal following oral administration, with systemic

Ranolazine, utilized in management therapy of anginal disorders, continues to be integrated into monolithic matrices whose excipients were mixtures at different ratios of the acrylic resin (Carbopol 971 P) hydrophilic pHdependent nature as well as an ethylcellulose (Ethocel N20/N50), water-insoluble and pH-independent polymers. Technological portrayal (drug particle morphology, mean weight, diameter, thickness, hardness and friability of tablets) was transported inside and out vitro drug release conduct was measured while using USP Type II (Paddle) apparatus. The result of different the Carbopol- Ethocel ratio, along with the drug-polymeric matrix ratio, was evaluated by simple factorial design using two independent factors. The outcomes demonstrated the appropriateness of Carbopol-Ethocel mixtures as matrix-developing material for ranolazine Extended release formulations. Mixture of the swelling qualities of Carbopol 971 P using the plastic qualities from the more hydrophobic Ethocel N20/N50 permitted appropriate modulation of ranolazine release. Mathematical research into the release kinetics established that the character of drug release in the matrix tablets was determined by drug diffusion and polymer relaxation and for that reason adopted non-Fickian or anomalous release. The developed extended release matrix tablets of Ranolazine prepared with monolithic matrices release as much as 12 hrs. The factorial study signifies a great correlation coefficient (.98317). The result was determined by both independent factors of hydrophilic and hydrophilic polymer.

Article · Jan 2011


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